Eric Gorr offers both 265cc and 295cc big bore kits for the KX 250, so there's no doubt you can go a lot bigger if you want to. Those kits may or may not require power valve mods. If you're wondering about an oversized piston for a near-stock bore and not a big bore kit then I'm not sure what the answer is.
I would think the mod required, if any, would pertain to the center flapper valve and not to the drum valves on the sides.
Anyone else?